Our research group pioneers innovative drug delivery systems and materials science, with a patent portfolio featuring advancements in mesoporous materials, pharmaceutical vehicles, and stem cell technologies. These patents highlight our commitment to overcoming key challenges in drug delivery and biomedical applications.
Porous silica material for use as a pharmaceutical or dietary active ingredient
Inventors: R. Csikasz, T. Bengtsson, N. Kupferschmidt, A. Garcia-Bennett
Filed: 26/06/2020
A porous silica material for use as a pharmaceutical or dietary active ingredient having pores in the mesoscale range (2-50 nm), wherein the average pore size of the pores in the mesoscale range is in the range of 2 to 25 nm, and the pore size distribution (PSD) in the mesoscale range is such that at least 80% of the pores fall within the range of 2 to 25 nm.
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Patent No: US12121612B2
Complexes and compositions comprising protocol and uses thereof
Inventors: A. Garcia-Bennett, M.H.O Lau, K.C. Giri
Filed: 31/01/2020
The present invention relates to complexes comprising probucol or derivatives thereof and mesoporous silica, methods for producing such complexes and uses thereof. The present invention also relates to uses of the complexes in the treatment of inflammation- and oxidation-related diseases and disorders.
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Patent No: US20220096398
Method for stem cell differentiation in vivo by delivery of morphogens with mesoporous silica and corresponding pharmaceutical active ingredients
Inventors: A. Garcia-Bennett, E. N. Kozlova
Filed: 01/11/2016
A pharmaceutical active ingredient for cell differentiation to alleviate cell and cell-related deficiencies in mammals comprising porous silica containing a releasable agent capable of contributing to a cell environment conducive for stem cell differentiation in co-implanted stem cells and/or in endogenous stem cells.
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Patent No: US10273453B2
Method for manufacturing mesoporous materials, materials so produced and use of mesoporous materials
Inventors: A. Garcia-Bennett
Filed: 29/10/2013
The present invention relates to a new synthetise for the preparation of mesoporous structures including mesoporous materials with chiral morphologies and mesoporous materials with local or surface chirality. The method can be used for manufacturing controlled drug delivery devices, for example for delivery of folic acid, and fluorescent particles.
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Patent No: US9409783B2
Method for manufacturing a nanoporous framework and a nanoporous framework thus produced
Inventors: A. Garcia-Bennett
Filed: 13/12/2011
The invention concerns a method for manufacturing nanoporous metal oxide or metal active sites frameworks in which the metal oxide precursor is distributed into the framework in the form of a metal soap surfactant. The invention also covers a nanostructure framework comprising metal oxide active sites which are evenly distributed in the framework.
Patent No: 8075867
Super-saturating delivery vehicles for poorly water-soluble pharmaceutical and cosmetic active ingredients and suppression of crystallisation of pharmaceutical active ingredients
Inventors: C. Zhou, X. Xia, A. Garcia-Bennett
Filed: 14/09/2011
A pharmaceutical or cosmetic composition, comprising a substantially poorly water-soluble pharmaceutical active ingredient; and a nanoporous folic acid material, wherein the active pharmaceutical ingredient is incorporated inside the nanoporous channels of the particles.
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Patent No: US9757456B2
Enhanced folic acid fluorescent material, multifluorescent porous compositions of matter and potential applications thereof
Inventors: A. Garcia-Bennett, C. Zhou
Filed: 16/03/2011
A method for the preparation of enhanced fluorescent folic acid mesoporous material, multifluorescent mesoporous materials, their novel properties and applications such as: a mesoporous fluorescent composition suitable for printing identification marks on metals, glass, plastic, ceramics, or paper which are visible only when excited by an external radiation; and applications in life science applications such as diagnostic, biodistribution markers, and targeted drug delivery applications.
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Patent No: US20130058987A1
Method for manufacturing a nonporous alumina based materials with controlled textural and particle size nd nonporous obtained by said method
Inventors: A. Garcia-Bennett
Publication: 09/11/2010
A method for the preparation of an inorganic porous oxide material, comprising the following steps: a) dissolving an alumina precursor in a mixture of a non-aqueous solvent and an acid; b) dissolving a pore agent in a non-aqueous solvent; c) mixing together the solutions obtained in step a) and b); d) adding a morphology controller to the reaction mixture of step c); e) evaporating the reaction mixture of step d); and f) removing the morphology controller and the pore agent from the product of step e).
Publication No: 20100310848